Perioperative pain
Conditions
Interventions
Control group:No
Experimental group:Adjust opioid dosage according to pupil variance index
Sponsors
Bethune International Peace Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-II; 2. Aged 18-80 years; 3. Body mass index (BMI) 20-30 kg/m^2; 4. With normal cognitive function.
Exclusion criteria
Exclusion criteria: 1. A history of ophthalmic diseases (such as Addy syndrome, Horner's syndrome or Sjogren's disease); 2. Neurological or metabolic diseases; 3. Ophthalmic surgery, medications that interfere with the autonomic nervous system (such as beta-blockers, anticholinergic drugs); 4. Use of chronic pain or preoperative analgesics within 2 weeks, use of pacemaker or arrhythmia; 5. History of allergy to narcotic drugs; 6. COVID - 19; 7. Cerebral hemorrhage or stroke; 8. Dysfunction of important organs such as heart, brain and kidney; 9. A history of substance abuse or mental illness; 10. A history of depression or sleep disorders requiring sedatives, antidepressants or other medications; 11. Patients or family members refuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale, NRS;Intraoperative dosage of remifentanil; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remifentanil or propofol consumption rate;PACU (postanesthesia care unit) residence time; | — |
Countries
China
Contacts
Public ContactWang Jingbao
Bethune International Peace Hospital
Outcome results
None listed