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Effects of different anesthesia methods (general anesthesia or general anesthesia combined with regional nerve block, etc.) and anesthesia drugs (dexmedetomidine, lidocaine, dexamethasone, magnesium sulfate, etc.) on immunity and postoperative intestinal function of patients undergoing surgery

Effects of different anesthesia methods (general anesthesia or general anesthesia combined with regional nerve block, etc.) and anesthesia drugs (dexmedetomidine, lidocaine, dexamethasone, magnesium sulfate, etc.) on immunity and postoperative intestinal function of patients undergoing surgery

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100054852
Enrollment
Unknown
Registered
2021-12-28
Start date
2021-12-25
Completion date
Unknown
Last updated
2022-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Interventions

General anesthesia group:Narcotic drugs
Regional nerve block group:Regional nerve block

Sponsors

Bethune International Peace Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. ASA grade I-II; 2. Aged 18-80 years; 3. Body mass index (BMI) 20-30 kg/m^2; 4. With normal cognitive function.

Exclusion criteria

Exclusion criteria: 1. Gastrointestinal dysfunction; 2. History of abdominal surgery; 3. Severe liver and kidney dysfunction; 4. Second- or third-degree heart block, baseline rate less than 50 beats/min bradyarrhythmia; 5. Mental disorders; 6. History of difficult airway or delayed extubation; 7. Opioid abuse; 8. Allergic to dexmedetomidine and other anesthetics; 9. Preoperative gastrointestinal bleeding (> 100 ml); 10. Emergency surgery; 11. The patient or family member refuses.

Design outcomes

Primary

MeasureTime frame
15-item quality of recovery scale;The time to first flatus;Number and proportion of immune cells;Time of first oral feeding;Incidence of delirium;

Secondary

MeasureTime frame
Time of first bowel movement;Sedation scores;NRS (Numerical Rating Scale) pain score;

Countries

China

Contacts

Public ContactWu Yu

Bethune International Peace Hospital

vwuyuv@163.com+86 18633487638

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026