Chemotherapy-induced nausea and vomiting
Conditions
Interventions
Group A:5-HT3 RA+NK-1 RA
Group B:5-HT3 RA+Dexamethasone
Group C:5-HT3 RA+Dexamethasone +Acupoint Application of Traditional Chinese Medicine Group
Sponsors
General Hospital of Southern Theatre Command
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. No gender restriction, aged >= 18 years, and pathologically diagnosed malignant tumors need to receive a medium emetic risk drug chemotherapy regimen; 2. ECOG physical status score 0~2; 3. No obvious abnormality in liver and kidney function, blood routine, electrocardiogram and other tests before chemotherapy, (liver and kidney function: creatinine 85 x 10^9/L, neutrophils > 1.5 x 10^9/L, leukocytes > 3.5 x 10^9/L); 4. The predicted survival period is more than 3 months; 5. No nausea or vomiting caused by tumor factors one week before enrollment, and no contraindications to chemotherapy; 6. Understand and voluntarily participate in this research and sign the consent form.
Exclusion criteria
Exclusion criteria: 1. Long-term use of hormones; 2. Patients with vomiting 24 hours before chemotherapy; 3. Patients who are pregnant or breastfeeding; 4. Those who are allergic to 5-HT3 RA, NK-1 RA, dexamethasone, and traditional Chinese medicine patches; 5. Nausea and vomiting caused by other non-tumor factors, those who are taking other emetic drugs or alcoholism.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Safety evaluation;Quality of life of cancer patients; | — |
Primary
| Measure | Time frame |
|---|---|
| rate of complete remission of vomiting;Nausea complete control rate; | — |
Countries
China
Contacts
Public ContactNie Wuyi
General Hospital of Southern Theater Command
Outcome results
None listed