Hip fractures
Conditions
Interventions
Group A:100 ml NS i.v. q12h preoperatively
1.5 g TXA i.v. q12h postoperatively for 3 days.
Group B:1.5 g TXA i.v. q12h preoperatively
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Over 65 years old; 2.Diagnosed with a primary, unilateral, recent hip fracture (femoral neck fracture or intertrochanteric fracture) by X-ray or CT scan; 3.Receiving hip arthroplasty.
Exclusion criteria
Exclusion criteria: 1.Complicated with multiple fractures or open fractures; 2.Active bleeding (like gastrointestinal bleeding, cerebral haemorrhage, etc); 3.Systematic thromboembolism (DVT, PE, etc); 4.Coagulation dysfunction (such as Preoperative INR >1.4, APTT >1.4 x normal, etc.); 5.Combined with serious neuromuscular diseases; 6.Allergic to TXA. 7.Patients who are dementially reduced or with cognitive dysfunction that cannot give informed consent, or decline to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hidden blood loss (HBL);Decline of hemoglobin level;Transfusion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Conventional coagulation indexes (PT, PTR, INR, PTA, APTT, TT);Conventional fibrinolytic indicators (FDP, D-D);Coagulation factors (II, V, VII, VIII, IX, X, XI, XII);Thromboelastogram(TEG);Time from fracture occurrence to admission;Time from admission to surgery;Wound complications (exudation, hematoma, infection);Incidence of thrombosis (deep vein thrombosis, pulmonary embolism);Hospitalization expenses;Length of stay;90-day mortality after surgery; | — |
Countries
China
Contacts
Public ContactHuang Wei
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed