Neural network changes casued by dexmetomidine
Conditions
Interventions
control group:saline
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 64 years 2. Patients with benign brain tumors, which is limited and does not compress the main brain functional network areas (such as DMN, ECN, FPN, etc.),and will performming surgery; 3. ASA (American Society of Anesthesiologists) physical status I or II grade; 4. BMI 18-30kg/m^2; 5. Right-hand.
Exclusion criteria
Exclusion criteria: 1. Recent history of general anesthesia; 2. Contraindications to MRI; 3. Intracranial lesions or systemic comorbidities; 4. History of anesthetic contraindications and allergyic reactions; 5. History of neurological or psychiatric disorders or structural abnormalities of the brain; 6. Evaluated as malignant brain tumor; 7. Pregnant or lactating women; 8. History of drug or alcohol abuse; 9. Patients with HR or BP decreased by more than 20% during dexmedetomidine infusion (emergency intervention at this time); 10.Refusing to participate in this researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brain functional magnetic resonance imaging indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety Assessment Scales;blood inflammatory markers;blood-brain protection-related factors; | — |
Countries
China
Contacts
Public ContactWang Tianlong
Xuanwu Hospital, Capital Medical University
Outcome results
None listed