Heart failure with reduced ejection fraction
Conditions
Interventions
experimental group:oseltamivir
control group:Nil
Sponsors
Sir Run Run Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with clinical diagnosis of heart failure (NYHA cardiac function II-IV); 2. Reduced ejection fraction (LVEF 18 years; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with end-stage renal failure (endogenous creatinine clearance eGFR less than 30 ml/min); 2. Patients with neurological diseases (epilepsy, convulsions and other mental diseases, depression); 3. Patients who cannot walk normally due to other comorbidities such as cerebral infarction hemiplegia or osteoarthritis; 4. Long-term bedridden patients; 5. Patients with active hepatobiliary pancreas and other digestive system diseases; 6. Patients with active gastrointestinal bleeding; 7. Patients with rheumatic immune system diseases; 8. Women preparing for pregnancy, pregnancy and lactation; 9. Patients with malignant tumors whose expected survival time is less than one year; 10. Hypotensive shock patients (systolic blood pressure less than 90mmHg, mean blood pressure less than 60mmHg).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six minute walking distance; | — |
Secondary
| Measure | Time frame |
|---|---|
| NT-pro BNP;NYHA cardiac function classification;Left ventricular ejection fraction;Left ventricular end-diastolic diameter;Tricuspid annular plane systolic excusion;Tei index;Related indexes of cardiopulmonary oxygen inhalation exercise;burden of Atrial fibrillation;Number of influenza attacks;Rehospitalization rate of heart failure; | — |
Countries
China
Contacts
Public ContactXiao Pingxi
Sir Run Run Hospital, Nanjing Medical University
Outcome results
None listed