Alzheimer's disease
Conditions
Interventions
Donepezil + anti-aging tablets (experimental group):Donepezil + anti-aging tablets
Sponsors
Hangzhou Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Meet the NINCDS-ADRDA probable AD dementia diagnostic criteria, with a course of disease >= 6 months; 2. Mini-Mental State Evaluation Scale (MMSE) (11 <= MMSE score <= 26, for subjects with primary education, 11 <= MMSE score<=24); 3. Aged 65 to 85 years, male or female; 4. Possess the education level of primary school or above, and have the ability to complete the tests stipulated in the program. 5. Receive a comprehensive neuropsychological assessment; Hachinski ischemia scale <= 4 points; and Hamilton Depression Scale (HAMD) <= 10 points; 6. Patients with deficiency of both qi and yin according to TCM syndrome differentiation; 7. There should be a stable escort, or at least 4 days a week, 2 hours a day to contact the escort. The escort should assist the patient throughout the trial; 8. No obvious positive signs in nervous system examination; 9. The patients and/or their family members signed the informed consent form and agreed to participate in all visits, examinations and treatments in accordance with the requirements of the trial protocol.
Exclusion criteria
Exclusion criteria: 1. Dementia caused by other diseases, such as vascular dementia, frontotemporal dementia, dementia with Lewy bodies, etc.; thyroid disease, parathyroid disease, alcoholism, drug poisoning, brain tumor, normal pressure hydrocephalus, etc. are excluded; 2. Routine laboratory research, including vitamin B12 level, folic acid level and thyroid hormone level; quantitative HIV antibody, syphilis serological examination, etc., to exclude dementia patients caused by other factors; 3. Patients or influential collaborators with a history of mental illness (such as schizophrenia); 4. Epilepsy, with a history of alcohol or psychotropic substance abuse; 5. Patients with major physical diseases such as cardiovascular, lung, liver, kidney, and hematopoietic system in the acute stage; 6. There are contraindications for magnetic resonance examination; 7. Severe abnormalities of hearing and vision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale to assess;community structure and composition of intestinal flora;Head-MRI; | — |
Countries
China
Contacts
Public ContactZhang Xueping
Hangzhou Seventh People's Hospital
Outcome results
None listed