Residual effects of muscle relaxants
Conditions
Interventions
Experimental group:Normal Saline 5ml
Experimental group1:Neostigmine 20µg/kg + glycopyrrolate 4µg/kg
Experimental group2:Neostigmine 40µg/kg + glycopyrrolate 8µg/kg
Experimental group3:Neostigmine 50µg/kg + glycopyrrolate 10µg/kg
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Elderly patients aged >= 65 years who have undergone cisatracurium-induced muscle relaxation; 2. ASA I-III grade; 3. Mini-Mental State Scale (MMSE) score > 23 points); 4. I understand this test and give informed consent.
Exclusion criteria
Exclusion criteria: 1. BMI = 25 m.kg-2; 2. Abnormal liver function (alanine aminotransferase or aspartate aminotransferase > 80U/L); 3. Abnormal renal function (creatinine>104umol/L); 4. The recent use of sedative-hypnotics, analgesics and antidepressants (within 5 half-lives of the drug); 5. Combined with other serious postoperative adverse reactions or contraindications of neostigmine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting 1-3 days after surgery in each group; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery room stay time after giving neostigmine;Postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactTong Jianbin
The Third Xiangya Hospital of Central South University
Outcome results
None listed