depression
Conditions
Interventions
Experimental group1:Intermittent Burst Rapid Pulse Stimulation in Functional Connectivity Localization Group
Experimental group2:Intermittent short bursts of rapid pulse stimulation in the classical coordinate positioning group
Healthy control group:None
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the International Classification of Diseases ICD-10 diagnostic criteria for depression and are diagnosed with mild depression and moderate depressive episodes; 2. Scored by 8<=HAMD<23 (Melzer et al., 2012); Chinese version of Mood Disorder Questionnaire (MDQ)<7; 3. Use the Brief International Neurological Psychiatry Interview 7.0.0 (M.I.N.I.7.0.0) to confirm that the subject is currently suffering from a depressive episode; 4. No gender restriction, aged 20 to 55 years; 5. Subjects who can understand and are willing to strictly abide by the clinical trial protocol to complete the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to magnetic resonance and TMS; 2. Patients who have been judged by the investigator or have been diagnosed with refractory depression (ineffective after 2 or more antidepressants in a sufficient amount and a full course of treatment); 3. Severe heart, liver, kidney disease, no history of thyroid, tumor, blood, rheumatism, malnutrition, nervous system and other diseases; 4. Schizophrenia, bipolar disorder, history of abuse of tobacco, alcohol and other psychoactive substances; 5. People at high risk of suicide; 6. The patient is a pregnant or lactating woman or a person planning to become pregnant; 7. Not taking immunomodulators and hormone preparations for at least half a year, and not taking antipyretic and analgesic drugs within 2 weeks; 8. Those who are deemed inappropriate by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Self-rating depression scale;Anxiety self-rating scale;Insomnia Severity Index Scale;Baker Suicidal Ideation Scale;Visual analogue scale; | — |
Countries
China
Contacts
Public ContactZang Yufeng
The Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed