Effect of Esketamine on Rebound Pain after Brachial Plexus Block: A Prospective, Double-Blind, Randomized Controlled Trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100054648

Enrollment

Unknown

Registered

2021-12-23

Start date

2021-12-22

Completion date

Unknown

Last updated

2022-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic upper limb fracture surgery

Interventions

Experimental group:Ultrasound guided single supraclavicular brachial plexus block with 0.375% ropivacaine + 0.5 mg / kg esmketamine 30ml

Control group:Ultrasound guided single supraclavicular brachial plexus block with 0.375% ropivacaine 30ml

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 60 years; 2. American Society of Anesthesiologists (ASA) classification: I-II; 3. Elective open reduction and internal fixation of the upper extremity.

Exclusion criteria

Exclusion criteria: 1. Contraindications for nerve block (abnormal bleeding or coagulation, local or systemic infection); 2. Patients with a history of chronic pain or long-term use of sedative and analgesic drugs; 3. Patients with a history of neurological, psychiatric or neuromuscular diseases; 4. Patients who refuse to receive treatment; 5. Refused to accept ultrasound-guided supraclavicular brachial plexus block anesthesia; 6. Bilateral upper limb surgery; 7. BMI=25 kg/m^2; 8. Patients with multiple injuries who need other surgery or pain medication; 9. Patients with preoperative nerve injury; 10. Patients with known hypersensitivity to ropivacaine or esketamine and chronic pain reliever users; 11. Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure over 180/100mmHg); 12. Untreated or undertreated hyperthyroidism (hyperthyroidism) patients; 13. Patients who do not have sufficient Chinese language ability and have a clear understanding of the Numerical Rating Scale (NRS) for pain cannot cooperate with patients in pain evaluation; 14. Patients and their families refuse to sign the informed consent; 15. Those who refuse to use PCIA after surgery.

Design outcomes

Primary

Measure	Time frame
Incidence of rebound pain;	—

Secondary

Measure	Time frame
Heart rate;Onset time of sensory block;Onset time of motor block;Duration of block;Incidence of adverse reactions;Time of the most severe pain;Evaluation of patients' satisfaction with perioperative experience;	—

Countries

China

Contacts

Public ContactZhu Shiyao

Xuzhou Cancer Hospital

476113149@qq.com+86 13852155340

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026