Parkinson's disease
Conditions
Interventions
Experimental group1:Tai Chi
Experimental group2:Combined resistance and stretching exercise
Sponsors
Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Primary Parkinson's disease, Hoehn & Yahr stage 2~3; 3. Stable medication (drug regimen is stable for more than 1 month); 4. Able to stand independently and walk with or without assistive devices; 5. Residents living in Hangzhou; 6. MMSE score: primary school>20 points; middle school and above>24 points.
Exclusion criteria
Exclusion criteria: 1. The subject is currently participating in any other behavioral or pharmacological or exercise intervention research project; 2. Depression or other mental illness; 3. Cardiovascular and cerebrovascular diseases (heart disease, stroke, hypertension, systolic blood pressure exceeding 160mm Hg); 4. Take antibiotics within the past month; 5. Movement-limiting diseases, such as knee arthritis, rheumatism, gout, visual impairment, neurogenic muscle atrophy; 6. Vulnerable groups, including mental illness, cognitive impairment, critically ill patients, pregnant women, illiterate, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor Symptoms-Parkinson's Disease Rating Scale;Cognitive Function-Simple Intelligent Mental State Examination Scale;Cognitive Function - Montreal Cognitive Assessment Scale;Nonmotor Symptoms-Nonmotor Symptoms Assessment Scale;Anxiety Levels - Hamilton Anxiety Scale;Depressive symptoms - Hamilton Depression Scale;Gait-Freezing Gait Questionnaire;Living Independence - Modified Barthel Index Scale;Balance Function - Berg Balance Scale;Quality of Life-Parkinson's Disease Quality of Life Scale;Physical Activity Levels - Physical Activity Scale for Older Adults;Tactile Condition - Tactile Function Experiment;Brain morphology and structure;30 second chair standing test;muscle synergy;ground reaction force;Composition of intestinal flora;Body posture;gait;Electromyography;Height;Body weight;Waistline;Body fat rate;Fat mass;Muscle mass;heel-knee-tibia test;Proprioception test;anticipatory postural adjustment;compensatory postural adjustment; | — |
Countries
China
Contacts
Public ContactLyu Wen
Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed