Study of 30-minute diaphragm variation rate, 0.1-second Airway closure pressure and D-RSBI scoring model in weaning patients with severe pneumonia

Study of 30-minute diaphragm variation rate combined with 0.1-second airway closure pressure and diaphragm-associated shallow rapid breathing index in severe pneumonia patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100054631

Enrollment

Unknown

Registered

2021-12-22

Start date

2022-06-01

Completion date

Unknown

Last updated

2022-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Community acquired pneumonia

Interventions

Evacuation Success Group:None

Evacuation Failure Group:None

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosis of severe pneumonia (1) Mechanical ventilation is required for endotracheal intubation; (2) Vasoactive drugs are still required for septic shock after active fluid resuscitation. (3) Respiratory rate >= 30 times/min; (4) Oxygenation index =7.14 mmol/L; (8) Systolic blood pressure <90mmHg requires aggressive fluid resuscitation. 2. Need to use invasive ventilator to assist ventilation therapy. 3. The patients themselves or their legal guardians agree to participate in this clinical study and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Abnormal respiratory mechanics caused by previous lung resection and chest wall deformity; 2. Neuromuscular junction-related diseases, diaphragm paralysis, etc.; 3. There are respiratory center inhibitory factors; 4. Pregnancy; 5. Pleural effusion>3cm, pneumothorax, mediastinal emphysema; 6. Abdominal hypertension syndrome; 7. Presence of flail chest or rib fractures.

Design outcomes

Primary

Measure	Time frame
30-minute diaphragmatic variation;0.1 Second Airway closure pressure;Diaphragmatic relative shallow rapid respiration index;Serum albumin;	—

Countries

China

Contacts

Public ContactLuo Wentao

Meizhou People's Hospital

wentaoluo@163.com+86 13727601032

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026