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Establishing biomarkers for knee arthrofibrosis after anterior cruciate ligament reconstruction by single cell sequencing

Establishing biomarkers for knee arthrofibrosis after anterior cruciate ligament reconstruction by single cell sequencing

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100054621
Enrollment
Unknown
Registered
2021-12-21
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee arthrofibrosis

Interventions

Postoperative adhesion group:None
Postoperative non-adhesion group:None

Sponsors

The Sixth People's Hospital Affiliated to Shanghai Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients with clinical diagnosis of anterior cruciate ligament injury combined with knee joint adhesion, who underwent anterior cruciate ligament reconstruction and joint release, aged 18 to 65 years; 2. Complete at least 6 weeks of rehabilitation after ACL reconstruction, and the extension angle is less than 5 degree and/or the flexion angle is less than 130 degree.

Exclusion criteria

Exclusion criteria: 1. Anterior cruciate ligament reconstruction combined with other structural damage repair operations (including multi-group ligament reconstruction, meniscus transplantation and articular cartilage operations, etc.); 2. Patients after anterior cruciate ligament revision; 3. Patients with infectious diseases, musculoskeletal fibrotic diseases, neuromuscular diseases, and rheumatic immune diseases; 4. Adhesion of the knee joint caused by abnormal positioning of the anterior cruciate ligament tunnel or concave intercondylar impingement.

Design outcomes

Primary

MeasureTime frame
Transcription expression characteristics;

Countries

China

Contacts

Public ContactZhao jinzhong

The Sixth People's Hospital Affiliated to Shanghai Jiaotong University

zhaojinzhong@vip.163.com+86 18930177160

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026