End-stages renal disease
Conditions
Interventions
Control group:Traditional hemodialysis induced dialysis therapy
Experimental group:New sequential induction therapy of CRRT, hemodiafiltration and hemodialysis
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. At least 18 years old, regardless of gender; 2. Patients diagnosed with chronic renal failure and indicated for blood purification treatment, including uremic pericarditis, uremic encephalopathy, severe hyperkalemia, severe metabolic acidosis, pulmonary edema caused by water overload and other uremic complications; Patients with poor nutritional status, excessive water load, fatigue, cognitive impairment, metabolic acidosis, hyperkalemia and hyperphosphatemia that failed conservative treatment due to renal failure; 3. No previous history of blood purification treatment.
Exclusion criteria
Exclusion criteria: 1. Enter hemodialysis due to acute renal insufficiency and have no previous history of kidney disease; 2. Short-term conversion to peritoneal dialysis; 3. Kidney transplantation is planned during the trial period; 4. Mental disorders can not cooperate with treatment; 5. Pregnant and lactating women; 6. Have a previous or current malignant tumor (except excised non-melanoma skin cancer and carcinoma in situ); 7. History of severe allergies, such as allergic asthma, anaphylactic shock, severe gastrointestinal symptoms, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death;Rehospitalization rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure; | — |
Countries
China
Contacts
Public ContactXu Chengyun
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed