diabetes
Conditions
Interventions
Experimental group:acupoint injection of mecobalamin at acupoint Zusanli
Control group:Mecobalamin intramuscular injection on hip muscle
Sponsors
Tianjin Medical University Zhu Xianyi Memorial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with type 2 diabetes; 2. Diabetic peripheral neuropathy with stable TCSS greater than 5; 3. Glycated hemoglobin greater than 7; 4. No nutritional neurological drugs have been used in the past 2 weeks; 5. Aged 18 to 60 years; 6. No lower extremity, knee joint trauma, surgery, and no release of nerve poisons.
Exclusion criteria
Exclusion criteria: 1. MR examination contraindications, cochlear implants, pacemakers and artificial stent implanters, claustrophobia; 2. Women who are pregnant, planning to become pregnant or breastfeeding; 3. Exclude the following diseases: (1) Cervical and lumbar spondylosis, infectious polyneuritis, chronic alcoholism, thyroid disease, drugs, poisoning, tumors, cerebrovascular sequelae, osteoarthritis, peripheral vascular disease, and peripheral neuropathy caused by genetics and other reasons: (2) Foot ulcer, infection and edema: (3) ABI<0.9; d) ALT and AST exceed 2 times the upper limit of normal, and serum creatinine exceeds the upper limit of normal. 4. Patients with severe organ diseases or combined with other serious primary diseases, mental illness, and patients with poorly controlled hypertension (blood pressure exceeds 160/100 mmHg after using antihypertensive drugs); 5. Patients with diabetic ketosis, ketoacidosis and severe infection within the past half month; 6. Those who have experienced bleeding or have bleeding tendency in the past 2 months; 7. Those with allergies: 8. The investigator believes that the patient is not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Toronto Clinical Neuropathy Score;Anisotropy of water molecules;Average degree of diffusion; | — |
Countries
China
Contacts
Public ContactYu Wenjuan
Tianjin First Central Hospital
Outcome results
None listed