Adenovirus pneumonia
Conditions
Interventions
Experimental group:Atomization inhalation of interferon a2b
Control group:Atomization inhalation of normal saline
Sponsors
Kunming Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 4 Years
Inclusion criteria
Inclusion criteria: 1. Aged 3 months to 4 years, male or female; 2. Those with onset within 72 hours; 3. The clinical diagnosis is common adenovirus pneumonia, and the diagnostic criteria are in accordance with the "Guidelines for the Diagnosis and Treatment of Adenovirus Pneumonia in Children (2019 Edition)"; 4. Adenovirus test positive (any one of the following positive is diagnosed as adenovirus infection): (1) Fluorescence PCR method or immunofluorescence method detects positive for adenovirus in sputum and (or) bronchoalveolar lavage fluid; (2) Serum adenovirus-IgM positive. 5. No other antiviral drugs and immunomodulatory preparations were used within one week before diagnosis and treatment.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to interferon; 2. Patients with systemic lupus erythematosus, psoriasis and other autoimmune diseases or immunodeficiency diseases; 3. Patients with severe basic diseases, including congenital heart disease, plastic bronchitis, bronchopulmonary dysplasia, liver and kidney dysfunction and severe malnutrition; 4. Patients with epilepsy or other central nervous system disorders; 5. Patients with HBV, HCV, HIV, EBV and other viral infection; 6. Patients with mixed bacteria, mold or mycoplasma infection before enrollment; 7. Refusing to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective rate;Virologic response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospitalization;Fever clearance time;Time to disappearance of pulmonary rales;Time to coughing disappearance;Time for breathing to return to normal;Time for heart rate to return to normal;Serum TNFa;Serum IFN?;Serum IL-2;Serum IL-4;Serum IL-6;Serum IL-10;Serum IL-17A;Serum procalcitonin;Serum C-reactive protein;Chest X-ray; | — |
Countries
China
Contacts
Public ContactFu Hongmin
Kunming Children's Hospital
Outcome results
None listed