Autism Spectrum Disorder
Conditions
Interventions
patient with autism group:None
Sponsors
Beijing Anding Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily or the guardian agrees to sign the informed consent; 2. The subject can cooperate with the collection of stool and urine samples; 3. Ages 3 to 6, 12 to 17 years (subject to the day of signing the informed consent form), male or female; 4. By a child psychiatrist (above the deputy director) according to "Autism" in the "Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, DSM-V" published by the American Psychiatric Association Diagnostic Observation Schedule (ADOS)" and "Autism Diagnostic Interview-Revised (ADI-R)" for patients diagnosed with autism; 5. (Only for autistic patients) Within 30 days before signing the informed consent form, score at least two points using the following scales: (1) Autism Behavior Scale (ABC) > 70 points (total score >= 67 points indicates autism-like symptoms); (2) Childhood Autism Rating Scale (CARS) > 34 points; (3) Social Response Scale (SRS) > 75 points (mild > 60 points, moderate to severe > 90 points). 6. (For healthy children only) Medical history and surgical history confirming never been diagnosed with autism spectrum disorder, height, weight, vital signs, physical examination, urine routine, stool routine, no mental, language, social Developmental disability, no gastrointestinal abnormalities.
Exclusion criteria
Exclusion criteria: 1. Currently or once diagnosed with other mental retardation diseases of children or adolescents, including but not limited to: childhood schizophrenia, mental retardation, language development disorders, children's disintegrating neurological disorder, Rett's syndrome, Asperger's syndrome, selective mutism, etc.; 2. Previous history of autoimmune diseases, including but not limited to: rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, Sj?gren's syndrome, Hashimoto's thyroiditis, toxic diffuse goiter, autoimmune hemolysis anemia, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, psoriasis, glomerulonephritis, nephrotic syndrome; 3. Antibiotic treatment planned or required within 2 months before screening or during the study; 4. Plan or must take probiotics within 2 weeks before screening or during the study; 5. Past history of human immunodeficiency virus HIV, HBV, HCV infection; 6. Patients deemed unsuitable for entry into the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composition of intestinal flora; | — |
Countries
China
Contacts
Public ContactChen Xu
Beijing Anding Hospital affiliated to Capital Medical University
Outcome results
None listed