Effects of esketamine on postoperative quality of recovery and pain in patients undergoing laparoscopic cholecystectomy

Effects of different doses of esketamine on postoperative quality of recovery in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100054508

Enrollment

Unknown

Registered

2021-12-19

Start date

2021-12-10

Completion date

Unknown

Last updated

2022-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Benign gallbladder disease

Interventions

Experimental group1:0.2mg/kg esketamine

Experimental group2:0.3mg/kg esketamine

Control Group:normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Planned elective laparoscopic cholecystectomy 2. Agree to participate in this research and sign the informed consent; 3. Patients aged 18 to 65 years in junior high school and above; 4. ASA I or II; 5. BMI18-25kg/m2.

Exclusion criteria

Exclusion criteria: 1. Malignant hypertension; 2. History of chronic pain; 3. Mental history, central nervous system damage; 4. History of surgical anesthesia; 5. Psychotropic drug users; 6. Severe liver and kidney insufficiency; 7. Patients with severe cardiovascular disease and high intraocular pressure; 8. Patients with hyperthyroidism; 9. Use of any pain reliever sleeping pills within the past 4 weeks; 10. Patients using PCA; communication disorders.

Design outcomes

Primary

Measure	Time frame
The quality was recovered 24 hours after surgery;	—

Countries

China

Contacts

Public ContactWang Liwei

Xuzhou Central Hospital

18952170255@163.com+86 18952170255

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026