None listed
Conditions
Interventions
Experimental group 1:Anesthesia induction 6.25mg promethazine intravenous bolus
Control group 1:Anesthesia induction normal saline 1ml intravenous bolus injection
Experimental group 2:Promethazine 6.25mg intravenous patient-controlled analgesia (PCIA)
Control group 2:Metoclopramide 50mg PCIA
Sponsors
Gansu Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, BMI 15-30kg/m^2, ASA grade I-II; 2. Be able to understand and sign the informed consent form, and cooperate with the completion of intervention and assessment; 3. The operation time is 1 to 4 hours, and the postoperative hospitalization is more than 72 hours.
Exclusion criteria
Exclusion criteria: 1. Patients with asthma, mechanical intestinal obstruction, and angle-closure glaucoma; 2. Confirmed/suspected history of alcohol, opioid or other drug abuse; 3. Preoperative coma, intellectual disability, mental symptoms, cardiovascular disease, liver and kidney insufficiency, and ST segment prolongation on preoperative electrocardiogram; 4. Those admitted to ICU after operation; 5. Those who are allergic to promethazine; 6. History of nausea and/or vomiting within 24 hours after surgery, history of anti-emetic drug treatment within 24 hours after surgery, and history of chemotherapy within 4 weeks before surgery; 7. Participate in other clinical studies within 3 months before being enrolled in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of post-operative recovery; | — |
Countries
China
Contacts
Public ContactYan Wenjun
Outcome results
None listed