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A randomized, parallel, double-blind, matrix-controlled, multi-center clinical study of compound clobetasol propionate ointment (Kinnewer) in the treatment of palmoplantar pustulosis

A randomized, parallel, double-blind, matrix-controlled, multi-center clinical study of compound clobetasol propionate ointment (Kinnewer) in the treatment of palmoplantar pustulosis

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100054494
Enrollment
Unknown
Registered
2021-12-18
Start date
2022-03-01
Completion date
Unknown
Last updated
2022-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Palmatoplantar pustulosis

Interventions

Control group:blank matrix

Sponsors

Ruijin Hospital Affiliated to Shanghai Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for palmoplantar pustulosis, with a history of more than 3 months; 2. Aged 18 to 65 years, gender is not limited; 3. Voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Those who are known to be allergic to Ginnewer and other ingredients of this product, or have a history of allergy to external hormones or external retinoids; 2. Patients with bacterial and viral skin diseases (such as chickenpox, pyoderma, post-vaccination, herpes simplex, herpes zoster), fungal skin diseases, syphilitic skin lesions, skin tuberculosis within four weeks; 3. Diagnosed with sweaty eczematoid dermatitis, continuous acrodermatitis, pustular bacterial eruption; 4. Use at sites with significant inflammation, erosion or infection; 5. Skin lesions involving other parts of the body; 6. Have used other topical skin drugs (excluding moisturizers) within 2 weeks before enrollment; 7. Systemic application of hormones, acitretin, immunosuppressive agents, biological agents and phototherapy 1 month before enrollment; 8. Those who are pregnant, breastfeeding and those who plan to become pregnant; 9. Participate in other clinical investigators within the past 1 month; 10. There are mental disorders or the doctor thinks that it is not suitable to participate in the clinical research.

Design outcomes

Primary

MeasureTime frame
PPPASI 75;

Secondary

MeasureTime frame
PPPASI 90;PPPASI 50;PPPASI 25;

Countries

China

Contacts

Public ContactLi Xia

Ruijin Hospital Affiliated to Shanghai Jiaotong University

drlixia@126.com+86 13601627536

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026