carotid artery stenosis
Conditions
Interventions
Group G:changes to hemodynamic parameters such as stroke volume to guide fluid isometrics
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
45 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective carotid endarterectomy; 2. Aged 45-64 years, ASA grade III or V; 3. BMI18.5-24.0 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Severe anemia; 2. Severe cardiopulmonary dysfunction; 3. Education level below middle school; 4. Preoperative Mini-mental State Examination (MMSE) score <= 24 points; 5. Severe liver and kidney dysfunction and coagulation dysfunction; 6. Patients with poorly controlled chronic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mean value of oxygen saturation (rScO2) in the regional brain tissue on the surgical side;Mean change of rScO2 on the operation side from baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| The minimum value of rScO2 on the surgical side;Relative maximum change in rScO2;Contralateral mean rScO2;Contralateral mean value of rScO2 change;Contralateral minimum rScO2;Contralateral maximum change in rScO2;Blood gas analysis;Blood IL-6 and S100ß protein levels;Cognitive level three days after surgery;Neurologic outcome; | — |
Countries
China
Contacts
Public ContactLi Juan
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed