osteopenia
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50-70 years, female subjects with natural menopause for more than 3 years; 2. After dual energy X-ray absorptiometry, -2.5 < T value < -1, which is in line with the diagnosis of low bone mass; 3. The subjects voluntarily participate in the research and sign the informed consent; 4. No contraindications for fMRI scanning, right-handed; 5. Able to understand the research content and cooperate to complete the research; 6. Have not received ear vagus nerve stimulation therapy or other physical therapy in the past 2 months; 7. Never had anti-osteoporosis treatment including calcium, VD, zoledronate, etc.
Exclusion criteria
Exclusion criteria: 1. History of metabolic bone disease (eg, hyperparathyroidism, hyperthyroidism, Cushing's syndrome, osteomalacia, liver and kidney failure, and diabetes). 2. Previous fractures or femoral head necrosis, and the examination site has a history of surgery or implants. 3. Inflammation and infectious diseases are not cured. 4. Long-term or current drinking, smoking, and drinking coffee and tea. 5. Long-term or current use of drugs known to affect bone metabolism (including bisphosphonates, calcium agents, estrogen and progesterone preparations, antiepileptic drugs, corticosteroids, thyroxine, anticoagulants, antiviral drugs, aromatase inhibitors, immunosuppressants, thiazolidinediones, etc.). 6. There are cardiovascular system diseases, endocrine system diseases, rheumatic immune diseases, neuropsychiatric diseases, malignant tumors, etc. (including arrhythmia, myocardial infarction, hypertension, coronary heart disease, diabetes, hyperthyroidism, hypothyroidism, rheumatoid arthritis, Crohn's disease, stroke, epilepsy, Parkinson's, insomnia, etc.). 7. Long-term or current use of drugs known to affect autonomic nerve function or cardiac function (including beta-blockers, angiotensin receptor antagonists, angiotensin-converting enzyme inhibitors, digoxin, anxiolytics). 8. There is a history of using tobacco, alcohol, tea, coffee, and energy drinks 24 hours before the inspection. 9. There is strenuous activity 24 hours before the examination. 10. Use antihistamines, hypnotics, sedatives, opioids, metformin, etc. 3 days before the examination. 11. Abnormal body temperature or use of antipyretic and analgesic drugs within 3 days before the examination. 12. The investigator believes that the patient has other conditions that are not suitable for participating in this study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| heart rate variability;questionnaire;biomarker of bone metabolism; | — |
Primary
| Measure | Time frame |
|---|---|
| bone mineral density;brain fMRI; | — |
Countries
China
Contacts
Public ContactLiu Bo
Outcome results
None listed