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Comparison between vonoprazan dual therapy and susceptibility-based tailored therapy as rescue regimens for Helicobacter pylori infection: a randomized controlled trial

Comparison between vonoprazan dual therapy and susceptibility-based tailored therapy as rescue regimens for Helicobacter pylori infection: a randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100054440
Enrollment
Unknown
Registered
2021-12-17
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori

Interventions

Control group:Individualized treatment

Sponsors

Army Specialty Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 70 years, male or female; 2. At least once failure of Hp eradication; 3. Gastroscopy diagnosis of chronic gastritis,with or without gastric ulcer or duodenal ulcer healed; 4. The rapid urease test , the urea breath test and anti-H.pylori culture was positive; 5. Signed informed consent.

Exclusion criteria

Exclusion criteria: 1. PPI, antibiotics, H2 receptor antagonists, bismuth agents, probiotics, potassium competitive acid blockers,and other drugs were used within four weeks before treatment; 2. Patients with allergies to the drugs used in this study; 3. Patients with previous gastric and esophageal surgery; 4. Serious concomitant diseases:heart,lung,liver,kidney,metabolic disease,mental illness or malignant tumors 5. Pregnant or lactating women, patients who had a birth plan during the study period; 6. Previous undergone dual therapy to cure Hp; 7. Culture negative.

Design outcomes

Primary

MeasureTime frame
eradication rate;

Secondary

MeasureTime frame
Patient compliance;Symptoms of digestive tract were assessed before and after treatment;

Countries

China

Contacts

Public ContactLan Chunhui

Army Specialty Medical Center

lanchunhui@tmmu.edu.cn+86 23 68757616

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026