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Electrophysiological Study of Vocal-Fold Mobility Disorders After Radiotherapy for NPC Patients via Magnetic Evoked Potential and Their Correlation with Voice Quality Assessment

Electrophysiological Study of Vocal-Fold Mobility Disorders After Radiotherapy for NPC Patients via Magnetic Evoked Potential and Their Correlation with Voice Quality Assessment

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100054425
Enrollment
Unknown
Registered
2021-12-17
Start date
2021-12-22
Completion date
Unknown
Last updated
2022-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dysphona for nasopharyngeal carcinoma

Interventions

Case group:None
Control group:None

Sponsors

The Second People's Hospital of Guangdong
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosed with nasopharyngeal carcinoma; 2. 1-10 years after radiotherapy; 3. Changes in sound quality as assessed by VHI and GRBAS; 4. Gender: not limited; 5. Aged 18 to 65 years.

Exclusion criteria

Exclusion criteria: 1. Recurrence of nasopharyngeal carcinoma; 2. Are undergoing radiotherapy and chemotherapy; 3. There are other head and neck tumors; 4. Voice disorders caused by non-radiotherapy factors, such as spasmodic dysphonia, vocal cord polyps, and cricoarytenoid dislocation; 5. Epilepsy; 6. Intracranial tumors; 7. Coagulation dysfunction; 8. Low platelet count; 9. The acute phase of infection; 10. Install artificially implanted electronic devices such as cardiac pacemakers; 11. Severe arrhythmia; 12. Infectious diseases, such as HIV, tuberculosis, COVID-19; 13. Severe cardiopulmonary dysfunction cannot tolerate examination.

Design outcomes

Primary

MeasureTime frame
central motor conduction time;motor root conduction time;compound muscular motor wave induced by laryngeal cortex;M-wave amplitude of the internal laryngeal muscle produced by stimulation of the vagus nerve root;resting motor threshold;active motor threshold;cortical silent period;Voice Disorder Index;Amplitude perturbation;voice self-rating scale;

Countries

China

Contacts

Public ContactHe Cui

The Second People's Hospital of Guangdong

hellojennyhe@126.com+86 15989026824

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026