None listed
Conditions
Interventions
Group A:Recombinant human type III collagen filler
Group B:Summax collagen filler
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 (inclusive), gender is not limited; 2. Those seeking to correct facial wrinkles, including frown lines, forehead lines, and crow's feet; 3. Severity score of static wrinkles >= grade 2; 4. The subjects voluntarily participated in this trial and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. The subject has local anesthetics (such as lidocaine, etc.) and collagen allergy; 2. The subject has a history of keloid or bleeding; 3. The subject has active inflammation in the area to be treated (such as local cysts, papules, nodules, pustules, cancer/precancerous lesions or any other skin disease); 4. Subjects suffering from clinically important diseases (such as major laboratory test abnormalities, myocardial infarction, stroke, cancer, connective tissue disease, systemic infection, uncontrolled diabetes, etc.) within 3 months before the start of the study; 5. Subjects may need to use immunosuppressive drugs during the trial (such as severe, uncontrolled asthma, rheumatoid arthritis, autoimmune diseases, etc.); 6. The subject has abnormal coagulation function or is using anticoagulant drugs, such as aspirin, non-steroidal anti-inflammatory drugs, etc., which will increase the degree of bleeding at the implantation site according to the judgment of the investigator; 7. Subjects plan to undergo major facial surgery (such as rhinoplasty, face lift, congenital defect repair, etc.) or medical cosmetic related treatments (such as laser, botulinum toxin injection, hyaluronic acid, etc.) during the research process; 8. The subject's face has been treated with wrinkle correction or botulinum toxin injection, laser or plastic surgery within 6 months; 9. Subjects should not use swine-derived medical products (control products) due to religion, ethnicity and other reasons; 10. The subject is planning to become pregnant, is pregnant or is breastfeeding during the study period. The subject must have a negative blood or urine pregnancy test before receiving the study treatment; 11. Subjects participated in clinical trials of other drugs or medical devices within 3 months before the screening visit of this clinical trial; 12. Subjects who are not suitable for participating in this trial due to other reasons such as poor compliance or perception disorder assessed by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Facial wrinkle grade; | — |
Countries
China
Contacts
Public ContactWu Sufan
Zhejiang Provincial People's Hospital
Outcome results
None listed