Invasive Aspergillus infection
Conditions
Interventions
Gold Standard:Traditional microbial detection methods (culture, microscopy, G test, GM test, etc.)
Index test:Aspergillus 
LFD 
combined 
with 
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The patients voluntarily participate in the research and sign the written informed consent; 2. Patients with pulmonary infection who are admitted to the ICU and need to carry out bronchoalveolar lavage according to the judgment of the clinician; 3. Have the following risk factors for Aspergillus infection: COPD, long-term steroid therapy, liver cirrhosis, influenza, diabetes, neutropenia, hematopoietic stem cell transplantation, organ transplantation, congenital and acquired immune deficiencies, chronic kidney disease, advanced age or other risk factors.
Exclusion criteria
Exclusion criteria: 1. Focus on people who have taken preventive medication for the prevention of Aspergillus infection and have not stopped taking the medication; 2. Diagnosed with chronic pulmonary aspergillosis; 3. Diagnosed with other species of pulmonary (such as Candida, Cryptococcus) fungal infection; 4. Pregnant patients; 5. Patients under the age of 14; 6. The test data is invalid due to the failure of sample extraction and other processing, and the laboratory diagnosis by multiple methods cannot be carried out according to the experimental requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1,3-ß-D-glucan detection (G test);Galactomannan test (GM test);Aspergillus antigen immunochromatographic rapid test (AspLFD);Aspergillus nucleic acid multiplex qPCR detection; | — |
Countries
China
Contacts
Public ContactMeng Xinke
Shenzhen Second People's Hospital
Outcome results
None listed