Effects of patient-controlled intravenous analgesia (PCIA) background-free and low-background dose infusion on postoperative hypoxemia in patients with gastrointestinal surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100054317

Enrollment

Unknown

Registered

2021-12-13

Start date

2021-12-14

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Experimental group:PCIA with a low background dosage infusion

Control group:PCIA without background dosage infusion

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective gastrointestinal tumor resection under general anesthesia who will receive postoperative PCIA; 2. Aged over 18 years; 3. BMI 18.5-30 kg/m^2; 4. ASA I-III level; 5. Voluntarily participated and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. SpO2 140 (males) or 130 (females) µmol/L and oliguria/anuria] or renal replacement therapy (e.g., dialysis); 4. Hepatic disease (liver enzyme concentrations twice the normal values); 5. Pregnancy or breastfeeding status; 6. Operation time > 5 h; 7. Plan for postoperative transfer to the intensive care unit; 8. Participation in another clinical trial in the previous 3 months.

Design outcomes

Primary

Measure	Time frame
the integrated area under an SpO2 saturation of 95% per hour 48 hours after operation;	—

Secondary

Measure	Time frame
the integrated area under an SpO2 saturation of 90% per hour 48 hours after operation;the integrated area under an SpO2 saturation of 85% per hour 48 hours after operation;hydromorphone consumption in 48h after the operation;the overall benefit of analgesic score (OBAS) at 24h and 48h after the operation;rest and activity numeric rating scale (NRS) pain scores at 4, 24, and 48 hours after surgery;ambulation time per hour in postoperative 48h;	—

Measure

Time frame

the integrated area under an SpO2 saturation of 90% per hour 48 hours after operation;the integrated area under an SpO2 saturation of 85% per hour 48 hours after operation;hydromorphone consumption in 48h after the operation;the overall benefit of analgesic score (OBAS) at 24h and 48h after the operation;rest and activity numeric rating scale (NRS) pain scores at 4, 24, and 48 hours after surgery;ambulation time per hour in postoperative 48h;

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Countries

China

Contacts

Public ContactNie Huang

The First Affiliated Hospital of Air Force Military Medical University

niehuang@163.com+86 13201630298

Outcome results