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Clinical application of high-throughput sequencing technology for detection of pathogenic microorganisms

Diagnostic value of high-throughput sequencing technology for detection of pathogenic microorganisms

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100054247
Enrollment
Unknown
Registered
2021-12-11
Start date
2022-01-10
Completion date
Unknown
Last updated
2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infectious diseases

Interventions

Gold Standard:Body temperature more than 37.3 degrees, white blood cells disorder, and/or increased biomarkers of infection and inflammation, imaging changes, and positive pathogen culture.
Index test:Metagenomics&#32
next&#32
generation&#32
sequencing,&#32
mNGS.&#32

Sponsors

Naval Medical Center, PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Inpatients over 18 years old from Navy Medical Center, with body temperature more than 37.3 degrees, white blood cells disorder, and/or increased biomarkers of infection and inflammation; 2. Sign the informed consent form and take the biological samples from the inpatients including but not limited to sputum, bronchoalveolar lavage fluid, blood, urine, pleural effusion, ascites, cerebrospinal fluid, and so on.

Exclusion criteria

Exclusion criteria: When one sample could not be performed for pathogen culture, it would be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Metagenomics next generation sequencing;Pathogen culture;—

Countries

China

Contacts

Public ContactCai Jin

Navy Medical Center, PLA

caij2013@163.com+86 18117068665

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026