Postoperative delirium (POD)
Conditions
Interventions
Control group:Saline
Insulin group 1:20U insulin
Insulin group 2:30U insulin
Sponsors
The General Hospital of Western Theater Command
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years; 2. ASA grade I~III; 3. BMI <= 28 kg/m^2; 4. Plan to undergo radical resection of esophageal cancer under general anesthesia; 5. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are contraindicated for nasal administration (such as nasal defects or disease); 2. Previous hypertension, diabetes; 3. History of insulin allergy; 4. History of alcohol abuse; 5. Unable to communicate before surgery (coma, deep dementia or language impairment, severe vision and hearing disorders); 6. MMSE score is too low [illiteracy < 17 points, elementary school level < 20 points, middle school level (including technical secondary school) < 24 points]; 7. Severe heart, liver and kidney disease; 8. Neurological disease or mental illness history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total incidence of POD in 3 days;TAU protein expression in serum;Aß protein expression in serum; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;Gender;Body mass index;Educational level;Operation time;ASA (American Stroke Association) classification;Preoperative hemoglobin concentration;Intraoperative blood loss;Intraoperative blood transfusion; | — |
Countries
China
Contacts
Public ContactHuang Qingqing
The General Hospital of Western Theater Command
Outcome results
None listed