Effects of hypothermic coronary artery bypass grafting on perioperative insulin and glucagon secretion and its regulation on blood glucose

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100054238

Enrollment

Unknown

Registered

2021-12-11

Start date

2018-06-01

Completion date

Unknown

Last updated

2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Interventions

Diabetic group:None

Non-diabetic group:None

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients undertaking hyppthermic on pump CABG surgery; 2. With or without diabetes.

Exclusion criteria

Exclusion criteria: 1. Emergency surgerysecond surgery or non-isolated CABG surgery; 2. Preoperative hemodynamic instability calls for vasoactive drugs; 3. Preoperative abnormal level of ALT, AST and creatinine; 4. NYHA degree of IV; 5. Aged 75 years; 6. Administration of long-acting insulin, glucagon-like peptide 1 analogues or dipeptidylpeptidase-4 inhibitor one day before surgery; 7. Administration of bolus insulin during operation; 8. Type 1 diabetes mellites or critical illness-induced hyperglycaemia (blood glucose >= 11 mmol/L without history of diabetes); 9. Blood loss > 800 mL.

Design outcomes

Primary

Measure	Time frame
blood glucose;glucagon;insulin;C peptide;IL-6;	—

Countries

China

Contacts

Public ContactAo Hushan

Fuwai Hospital, CAMS

aohushan@126.com+86 13910726304

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026