Lung cancer
Conditions
Interventions
IFI (Involved-Field Irradiation) group:Involved field
EIN (Elective Nodal Irradiation) group:Elective field irradiation
Sponsors
Wuwei Cancer Hospital of Gansu Province
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Histologically confirmed NSCLC; lymph node short diameter >= 10 mm,or FNA confirmed postive; 3. N0~2; 4. UICC TNM edition 8th, IIA~IIIB; 5. No prior RT for local lung lesion; 6. No prior chest RT; 7. Renal function, liver function and bone marrow function were normal (serum creatinine 9.5 g/dL; white blood cell count >= 3000/ml; platelet count >= 100,000/mL; 8. ECOG:0~2; 9. The expected survival >= 12 months; 10. Ability of subject to understand character and individual consequences of the clinical trial; 11. Written informed consent (must be available before enrolment in the trial).
Exclusion criteria
Exclusion criteria: 1. Patients who can't lie down for 30 minutes; 2. Tumor progression extensively involving the pleura; have cancerous pleural effusion; 3. Lose more than 20% of your body weight within six months; 4. Pregnancy (as confirmed by serum or urine ß-HCG test) or lactation; 5. Drug abuse or alcohol dependence; 6. HIV sufferers; 7. Having uncontrolled systemic, pulmonary or cardiac disease; 8. Serious comorbidities, including uncontrolled comorbidities (pulmonary insufficiency, cardiovascular, pulmonary, liver, kidney, diabetes, etc.), addiction, and/or mental illness, that prevent successful implementation of the trial programme; connective tissue diseases (e.g., scleroderma, systemic lupus) or a history of malignancy that might interfere with regimental treatment were excluded; 9. Implantation of a pacemaker or other metal prosthesis is enough to affect the recipient of radiotherapy; 10. Patients with poor compliance may not be able to complete treatment plans or receive required follow-up and examinations; 11. History of other malignancies (except cured skin cancer and stage 0 cervical cancer); 12. Received systemic immunotherapy or corticosteroid therapy; 13. Serum creatinine clearance < 30 ml/min; 14. There are contraindications to radiation therapy; 15. Participated in clinical trials of other drugs within 30 days prior to enrollment in this trial; 16. Incapacity for civil conduct or limited capacity for civil conduct; 17. Any medical history that, in the investigator's judgment, may interfere with trial results or increase patient risk; 18. Any conditions that the physician deems inappropriate for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lymph node recurrence rate;local tumor control rate;acute and chronic toxicity; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival,;specific survival overall;disease-free survival; | — |
Countries
China
Contacts
Public ContactZhang Yanshan
Wuwei Cancer Hospital&Institute
Outcome results
None listed