Melasma
Conditions
Interventions
Intervention group 1:Use Tricholoma matsutake essence 1 twice daily
Intervention group 2:Use Tricholoma matsutake essence 2 twice daily
Positive control group:Use arbutin essence twice daily
Placebo group:Use placebo essence twice daily
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Female
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Female volunteers with a diagnosis of moderate to severe melasma (mMASI value > 5.8 at background testing); 2. Aged 25-60 years; 3. Indoor workers; 4. Subjects were volunteering to participate in this project and signed an informed consent form before the start of the test.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women, or women who are planning to become pregnant within six months; 2. Those who have received whitening and spot treatment (including drugs, chemical peels, photoelectric therapy, etc.) in the two months prior to the study; 3. Those who have used hormonal drugs and immunosuppressants within the last month; 4. Patients with cosmetic contact dermatitis, the specific exclusion criteria are in accordance with GB/T17149.2-1997 Diagnostic Criteria and Treatment Principles of Cosmetic Contact Dermatitis; 5. Oral or topical whitening or spot-removal products within the past two months; 6. The presence of any facial skin disease affecting the diagnosis of melasma or other pigmentary diseases; 7. Serious heart, brain, liver, kidney, blood and other systemic diseases and immune deficiencies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mMASI (melasma area and severity index);Spot area;Optical density value of spot;Melanin index;ITA (individule type angle);Quality of life questionnaire for melasma patients; | — |
Countries
China
Contacts
Public ContactWang Xi
West China Hospital of Sichuan University
Outcome results
None listed