Hepatic carcinoma
Conditions
Interventions
Experimental group:Multimodal analgesia treatment
Control group:Conventional analgesia treatment
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients have been confirmed for primary hepatocellular carcinoma by clinical diagnostic criteria or needle biopsy; 2. Well-to-moderately preserved liver function as defined by the Child-Pugh stage A or B; 3. Barcelona (BCLC) phases B and C; 4. Aged 18-70 years, weight within 45-80 kg; 5. ECOG score <= 2 points; 6. American Association of Anesthesiologists (ASA) Grade I-II; 7. Patients voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: 1. History of severe cardiovascular, cerebrovascular and respiratory diseases; 2. History of severe drug allergy; 3. Long-term history of taking opioids; 4. Patients who are mentally retarded and unable to cooperate; 5. Patients have had brain injury, stroke and other central nervous system diseases with neurological sequelae; 6. Patients who have participated in other drug clinical research within 3 months, and the investigator believes that they are not suitable to participate in the clinical trial; 7. Patients within the contraindications of drug-eluting beads: growth of main portal vein tumors, severe portal hypertension, severe varices of the fundus of the stomach and esophagus and cardiac veins, risk of rupture and bleeding, severe renal insufficiency (creatinine <= 2 times the normal value); the tumor is huge, more than 70% of the total volume of the liver; the inferior vena cava cancer tumor grows; liver reserve function is poor or severe liver cirrhosis; systemic condition is poor or cachexia; severe arteriovenous fistula, not easy to embolize and block, diffuse liver cancer; lactating woman; and patients is known to be allergic to PVA or related compounds.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation assessment;Anxiety assessment;Postoperative comfort assessment;Pain belief assessment;Vital signs;Adverse reaction; | — |
Countries
China
Contacts
Public ContactLi Lupeng
He'nan Provincial People's Hospital
Outcome results
None listed