Colorectal cancer
Conditions
Interventions
Group 1:Lung-protective ventilation combined with deep neuromuscular blockade and low pneumoperitoneum pressure
Group 2:Conventional pulmonary ventilation combined with moderate NMB (neuromuscular blockade) and conventional pneumoperitoneum pressure
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male and female patients aged between 18 and 80 years old; 2. American Society of Anesthesiologists (ASA) physical status 44 defines as high risk).
Exclusion criteria
Exclusion criteria: 1. Pregnant or breast-feeding status; 2. Had a history of recent pulmonary infection or diagnosis of pneumothorax, giant bullae, chronic obstructive pulmonary disease; 3. Diagnosis of severe cerebral and cardiovascular dysfunction; 4. Diagnosis of chronic renal failure with dialysis; 5. Diagnosis of hepatic dysfunction (Child-Pugh grade B or C); 6. Diagnosis of immunologic or neuromuscular disease; 7. Had a history of prior lung or abdominal surgery; 8. Emergency or unplanned surgery; 9. Expected prolonged mechanical ventilation after surgery; 10. Allergies or contraindications to sevoflurane, propofol, or nonsteroidal anti-inflammatory drugs (NSAIDs); 11. Participated in other drug trials within 1 preoperative month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Pulmonary Complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neutrophil Elastase, NE;Angiopoietin, ANG2;Clara cell secretory protein, CC16;Modified Clinical Pulmonary Infection Score, mCPIS;Postoperative pulmonary complications, PPCs;Surgical rating scale, SRS;White blood cell, WBC;Neutrophils;Lymphocyte;C-reactive protein;Nuclear factor kappa-B, NF-?B;Tumor Necrosis Factor-a, TNF-a;IL-1ß;IL-6;Intraoperative ventilation index;Acute pain numerical rating scale;Chronic pain numerical rating scale;Post-operative pain when nausea/vomiting;Soluble receptor for advanced glycation end-products, sRAGE; | — |
Countries
China
Contacts
Public ContactYan Tao
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed