Gestational diabetes mellitus
Conditions
Interventions
Intervention group:Supplement of vitamin D3 with 2400 IU per day
Sponsors
Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women with gestational age of 24-28 weeks and diagnosed with GDM were first investigated; 2. Pregnants lived in Hefei, and planned to conduct antenatal examination and delivery at the research implementation site; 3. Single pregnancy; 4. Aged 18-40 years; 5. Voluntary participation in regular follow-up after informed; 6. Be able to answer the questionnaire clearly; 7. No diarrhea/taking stomach medicine 2-3 weeks before stool collection.
Exclusion criteria
Exclusion criteria: 1. Pregnancy with assisted reproductive technology; 2. Mental disorder; 3. Pregnancy complications; 4. Long-term drug use affected liver and kidney function; 5. Those who are unwilling to complete the questionnaire.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 25(OH)D level in pregnants and neonates;Maternal blood and cord blood glucose and lipid metabolism indicators;Detection of intestinal microbes in the feces of pregnant women in the second and third trimester of pregnancy;Untargeted metabolomics of maternal blood and cord blood in the second and third trimester of pregnancy;Neurodevelopmental screening for 6-24 months of age;Neurodevelopmental diagnosis (autism and attention deficit hyperactivity disorder) and intelligence for children 3-6 years old;Imaging examination of brain function in children aged 5-7 years; | — |
Countries
China
Contacts
Public ContactZhu Peng
Anhui Medical University
Outcome results
None listed