Chronic Hepatitis B
Conditions
Interventions
ETV(Entecavir) treatment goup:No
TDF(Tenofovir disoproxil fumarate) treatment goup:No
TAF(Tenofovir alafenamide fumarate) treatment goup:No
Combination treatment (ETV+TDF/TAF) group:No
Sponsors
Hwa Mei Hospital, University of Chinese Academy of Science
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years, no gender limit; 2. For patients with chronic HBV infection (HBeAg +/- chronic hepatitis B, liver cirrhosis, hepatocellular carcinoma), the diagnostic criteria are based on the Guidelines for Diagnosis and Treatment of Liver Cirrhosis, Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2019 Edition) and Guidelines for Prevention and Treatment of Chronic Hepatitis B (2019 Edition); 3. The indications for antiviral treatment comply with the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2019 Edition); 4. Volunteer to participate in the research, agree to cooperate with the researcher in specimen and data collection, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Mental illness, unable to cooperate to complete the project research; 3. Persons co-infected with HAV, HCV, HDV, HEV and HIV; 4. Severe circulatory, neurological and immune system diseases; 5. Subjects with poor compliance; 6. Other situations that the researcher believes are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| biochemical response;virological response;serological response;inflammation and immunological indicators;functional cure index; | — |
Countries
China
Contacts
Public ContactHu Airong
Hwa Mei Hospital, University of Chinese Academy of Science
Outcome results
None listed