Effect of different intraoperative inhaled oxygen concentrations on long-term neurocognitive function after off-pump coronary artery bypass grafting: a prospective study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100054192

Enrollment

Unknown

Registered

2021-12-10

Start date

2022-02-01

Completion date

Unknown

Last updated

2023-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive function

Interventions

Group A:Intraoperative normoxia inhalation at a minimum of 35%

Group B:Intraoperative high concentration oxygen inhalation at 80%

Eligibility

Sex/Gender

All

Age

60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Aged 0-85 years; 2. ASA class III-IV; 3. Proposed off-pump coronary artery bypass graft surgery.

Exclusion criteria

Exclusion criteria: 1. Acute coronary syndrome; 2. Severe cognitive impairment with baseline MoCA-BC score < 19; 3. Patients with right-to-left shunt heart disease; 4. Non-consent to participate in the study; 5. Congestive heart failure; 6. Hearing impairment.

Design outcomes

Primary

Measure	Time frame
MoCA-BC (Montreal Cognitive Assessment Basic Edition);	—

Secondary

Measure	Time frame
Myocardial infarction;Stroke;Pneumonia;Pulmonary atelectasis;Mortality;	—

Countries

China

Contacts

Public ContactFang Jun

The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)

fjjf123@sina.com+86 13170010298

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026