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Application of propofol combined with alfentanil general anesthesia in laryngeal microsurgery under support laryngoscope

Application of propofol combined with alfentanil general anesthesia in laryngeal microsurgery under support laryngoscope

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100054186
Enrollment
Unknown
Registered
2021-12-10
Start date
2021-12-10
Completion date
Unknown
Last updated
2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resection of vocal cord polyp under self-retaining laryngoscope

Interventions

Group A1:Fentanyl (concentration 1)
Group A2:Fentanyl (concentration 2)
Group A3:Fentanyl (concentration 3)

Sponsors

The First Affiliated Hospital of Nanchang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Male or female subjects; aged 20-65 years; 2. Mallampati grade I-II, BMI 18-24; 3. American Society of Anesthesiologists (ASA) physical condition classification system risk I~II; 4. The electrocardiogram was normal, the color ultrasound of the heart was normal, and the preoperative blood pressure was normal.

Exclusion criteria

Exclusion criteria: 1. Those with severe respiratory and circulatory diseases; 2. Those who have acute inflammation of the respiratory tract within 2 weeks and have not been cured; 3. Mallampati grading >= grade III, previously diagnosed sleep apnea syndrome (with more than 30 repeated episodes of apnea during sleep per night or sleep apnea hypopnea index (AHI) >= 5 times/hour accompanied by sleepiness and other clinical symptoms) symptom); 4. Preoperative biochemical examinations suggest renal dysfunction (serum creatinine > 177umol/L) or active liver disease; important organ dysfunction, combined with other system diseases, such as myocardial infarction, cerebral infarction, mental and nervous system history or taking related drug person; 5. Patients with cardiac pacemaker implantation in the past; 6. Known allergic to emulsion opioids; 7. Those who do not cooperate and cannot communicate; 8. The operation time is less than 5min, or more than 60min.

Design outcomes

Primary

MeasureTime frame
Hemodynamics;

Secondary

MeasureTime frame
Vanishing time of eyelash reflex;Dosage of Propofol;Steward Recovery Score;Cort, AT II, NE, E hormone levels in the two groups;

Countries

China

Contacts

Public ContactYu Qi

The First Affiliated Hospital of Nanchang University

910717524@qq.com+86 15870618929

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026