Bipolar depression
Conditions
Interventions
Experimental group:Combination therapy with rTMS and quetiapine
Control group:Combination therapy with sham stimulation and quetiapine
Sponsors
Shenzhen Kangning Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. 18-60 years old, Han nationality, right hand, male or female; 2. Diagnosed with bipolar I depression based on DSM-5; 3. Current depressive episode, HDRS-17 >= 17 and YMRS <= 4; 4. Drug-free (lithium, anticonvulsant, antipsychotic, antidepressant) before enrolled the study; 5. Understanding the study content and signing the informed consent; 6. Junior high school or above, and enough to understand the contents of neuropsychological tests.
Exclusion criteria
Exclusion criteria: 1. Main diagnosis is physical illnesses, physical illness-induced bipolar depression, or other mental disorders; 2. Any mood episode less than 4 times within 12 months; 3. Depression with mixed features; 4. With serious suicidal tendency, suicide item in HDRS-17 >= 3; 5. With severe physical diseases, previous craniocerebral trauma or surgery, previous history of epilepsy, and history of febrile convulsion in childhood; 6. With a history of severe drug allergy; 7. Alcohol or other psychoactive substance abuse; 8. Cannot accept rTMS or neuroimaging scan due to metal implants in the body or other medical conditions; 9. Pregnant or lactating women, plan to conceive, or contraceptive failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg Depression Rating Scale;Neuroimaging scan; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale, 17-items;Hamilton Anxiety Rating Scale;Young Mania Rating Scale;Clinical Global Impression;Pittsburgh sleep quality indexPittsburgh sleep quality index;MATRICS Consensus Cognitive Battery; | — |
Countries
China
Contacts
Public ContactBai Yuanhan
Shenzhen Kangning Hospital
Outcome results
None listed