Perioperative neurocognitive function
Conditions
Interventions
Remazolam toluenesulfonate group:Ramazolam for induction and maintenance of anesthesia
Conventional anesthesia group:No
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60-80 years, with no gender limitation; 2. Elective total hip arthroplasty (endotracheal intubation and mechanical ventilation); 3. ASA score was grade I or II; 4. BMI 18-30 kg/m^2; 5. Subjects clearly understand and voluntarily participate in the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Other operations or total hip replacement performed at the same time; 2. History of general anesthesia (endotracheal intubation) within the last 6 months; 3. Emergency surgery, hypovolemia, shock or coma; 4. Other anesthesia methods, such as inhalation anesthesia, epidural anesthesia, subarachnoid anesthesia, etc. should be combined with general intravenous anesthesia; 5. abnormal coagulation (PT or PT-INR >= 1.5 x ULN, APTT >= 1.5 x ULN); 6. Anemia or thrombocytopenia, Hb = 2.5 x ULN, TBIL >= 1.5 x ULN; 8. Abnormal renal function, urea or urea nitrogen >= 1.5 x ULN, and serum creatinine greater than the upper limit of normal value; 9. Acute heart failure, unstable angina pectoris, myocardial infarction within 6 months before screening, resting ecg heart rate = 160 mmHg during screening, and/or diastolic blood pressure >= 100 mmHg during screening) and sitting systolic blood pressure = 11.1 mmol/L during screening); 12. Have a history of drug abuse and/or alcohol abuse in the 2 years prior to screening, with alcohol abuse, i.e. drinking more than 2 units of alcohol per day on average (1 unit 14/30 = 360 mL beer or 45 mL 40% alcohol white wine or 150 mL wine); 13. Patients suffering from mental system diseases (schizophrenia, mania, bipolar disorder, insanity, etc.), and/or long-term history of taking psychotropic drugs and cognitive dysfunction; 14. Allergic or contraindicated to benzodiazepines, opioids, propofol, muscle relaxants and other drugs and their components; 15. Patients diagnosed as having difficulty in respiratory management (modified Markovner score grade IV); 16. Other circumstances that the investigator considers inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nu-DESC (Nursing Delirium Screening Scale) score;CAM-ICU (Confusion Assessment Method for the ICU) score;BDNF in venous blood;lncRNA BDNF-AS in exosome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction time of anesthesia;Postoperative recovery time;Stay time in postanesthesia care unit;Ramsay score;Heart rate, blood pressure, SpO2, respiration, BIS index;MOAA/S (modified observer's assessment of alert sedation) Score; | — |
Countries
China
Contacts
Public ContactWu Tong
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed