Perioperative neurocognitive dysfunction
Conditions
Interventions
NOX group:Monitor the NOX index and adjust the amount of remifentanil to maintain the NOX index close to 40
Sponsors
The First Affiliated Hospital of Ji'nan University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Participate voluntarily and have the ability to provide informed consent; 2. Patients undergoing spinal surgery in our hospital; 3. >= 60 years old, ASA I-II, BMI 18-30 kg/m^2; 4. Have not participated in the clinical trial research of other drugs 3 months before screening.
Exclusion criteria
Exclusion criteria: 1. Patients with previous neurological diseases or clinically obvious neurovascular diseases; 2. Preoperative Simple Mental State Examination (MMSE) score <23; 3. The expected difficulty of neuropsychological evaluation; 4. Related medical problems that may cause serious complications; 5. Blindness, deafness, non-native Chinese; 6. Previous surgery; 7. Severe perioperative complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory cytokines level after operation;Intraoperative anesthetic consumption;Pain during hospitalization after operation; | — |
Countries
China
Contacts
Public ContactLi Yalan
The First Affiliated Hospital of Ji'nan University
Outcome results
None listed