Gastrointestinal diseases
Conditions
Interventions
control group:Sufentanil 0.1ug/kg+ propofol 1.5mg/kg
experimental group:Sufentanil 0.1ug/kg+ remimazolam 7mg
Sponsors
Shanghai East Hospital (Affiliated East Hospital of Tongji University)
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. The age is over 60 years old, and the gender is not limited; 2. Patients receiving routine gastric and colonoscopy examinations; 3. American Society of Anesthesiologists ASA I-III grade; 4. BMI 18.5-30kg/m^2; 5. Informed consent, voluntarily participate in the trial, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are judged to be difficult to manage the respiratory tract (modified Markov score is grade IV); 2. Anemia or thrombocytopenia, Hb=2.5xULN, TBIL>=1.5xULN; 4. Abnormal renal function, serum creatinine is greater than the upper limit of normal; 5. A history of drug and/or alcohol abuse within 2 years prior to the start of the screening period. Alcohol abuse is an average of more than 2 units of alcohol per day (1 unit = 360 mL of beer or 45 mL of liquor with 40% alcohol content or 150 mL of wine); 6. Hypertensive patients whose blood pressure is not satisfactorily controlled by antihypertensive drug treatment (sitting systolic blood pressure >=160 mmHg during screening period, and/or diastolic blood pressure >=100 mmHg during screening period); 7. Sitting systolic blood pressure <=90 mmHg during the screening period; 8. Those who are allergic to or have contraindications to benzodiazepines, opioids, propofol, lidocaine and their drug components; 9. Those who have a history of abnormal surgical anesthesia recovery in the past; 10. Subjects deemed unfit for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Awakening time;Drug top-up times;Incidence of injection pain;Incidence of hypotension;Heart rate variability;Incidence of hypoxia;Incidence of respiratory depression; | — |
Countries
China
Contacts
Public ContactWang Yinglin
Shanghai East Hospital (Affiliated East Hospital of Tongji University)
Outcome results
None listed