Refractory gastroesophageal reflux disease
Conditions
Interventions
Sponsors
Beijing Pinggu District Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 18-65 years old; 2. The diagnosis is consistent with non-erosive RGERD; 3. TCM syndrome differentiation is in line with liver and stomach stagnation and heat syndrome; 4. The gastroscopy is basically normal, and superficial gastritis or atrophic gastritis is allowed; 5. Agree to perform 24h esophageal pH-impedance test and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. History of gastric, esophageal and duodenal surgery; 2. Drug-induced esophagitis, fungal esophagitis, erosive esophagitis, achalasia, hiatal hernia, eosinophilic esophagitis, immune-related esophageal diseases; 3. Suspected or confirmed to have malignant disease or have any early warning symptoms, and previous examinations found organic lesions of the digestive tract (digestive tract ulcer, digestive tract tumor, inflammatory bowel disease, etc.); 4. Have serious primary heart, liver, lung, kidney, pancreas, liver or serious diseases that affect their survival; 5. Disabled patients specified by law (blind, deaf, dumb, intellectually disabled, mentally disabled and physically disabled, etc.); 6. Suspect or have a history of alcohol or drug abuse; 7. Allergic constitution, such as those with a history of allergies to two or more drugs or food; or known allergies to the ingredients of this medicine; 8. Patients with mental system diseases, who cannot express the symptoms of the disease or cannot communicate with doctors normally; 9. Pregnant or lactating women, or women planning to become pregnant within 3 months; 10. Patients with RGERD due to poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Esophageal pH Monitoring DeMeester Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastroesophageal Reflux Disease Scale (GERDQ);TCM clinical symptom score;Hamilton Depression and Anxiety Scale score; | — |
Countries
China
Contacts
Public ContactWang Zhiqiang
Beijing Pinggu District Hospital of Traditional Chinese Medicine
Outcome results
None listed