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Goal-directed perfusion for the prevention of acute kidney injury after acute type A aortic dissection operations

Goal-directed perfusion for the prevention of acute kidney injury after acute type A aortic dissection operations

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100054124
Enrollment
Unknown
Registered
2021-12-09
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute type A aortic dissection

Interventions

adopt goal-directed perfusion (GDP) strategy during cardiopulmonary bypass (CPB) group:
conventional srategy according to our center group:None

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. >=18 years old; 2. Patients diagnosed with acute type A aortic dissection and undergoing total arch replacement surgery under cardiopulmonary bypass; 3. American Society of Anesthesiologists classification I-IV; 4. Signed written informed consent before the study.

Exclusion criteria

Exclusion criteria: 1. Patients with chronic kidney disease before surgery (receiving renal replacement therapy or eGFR (estimated glomerular filtration rate) <15mL/min/1.73m^2); 2. Anemia (preoperative HCT <30%); 3. Patients using ECMO or VAD in the perioperative period; 4. Perioperative cardiac arrest; 5. Heart transplantation; 6. Minimally invasive surgery; 7. Pregnant women; 8. Participate in other interventional investigators.

Design outcomes

Primary

MeasureTime frame
serum creatinine concentration;—

Secondary

MeasureTime frame
oxygen delivery index;clinical outcomes;—

Countries

China

Contacts

Public ContactLi Xin

Zhongshan Hospital, Fudan University

li.xin3@zs-hospital.sh.cn+86 13817697021

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026