Hip surgery
Conditions
Interventions
propofol group :patients received propofol general anesthesia
remimazolam group :patients received remimazolam general anesthesia
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Obtaining informed consent; 2. Age >= 60 years old and <= 90 years old; 3. Patients scheduled to receive hip surgery under general anesthesia; 4. American Society of anesthesiologists (ASA) grade I ~ III.
Exclusion criteria
Exclusion criteria: 1. Severe heart, lung, liver and kidney dysfunction; 2. Have a history of mental illness or long-term psychotropic drugs (dementia, schizophrenia), history of chronic analgesic drug use, history of alcoholism; 3. Patients with positive CAM before surgery; 4. Patients with preoperative Simple Mental State Questionnaire (SPMSQ) >= 8 errors, diagnosed as severe cognitive impairment; 5. Any cerebrovascular accident, such as stroke, transient ischemic attack (TIA), etc., occurred within 3 months; 6. Diabetic patients with severe diabetic complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macrovascular disease, diabetic nephropathy); 7. Patients with severe infection; 8. Preoperative PaO2<60mmHg or SpO2 < 92 %; 9. Participated in another clinical study of drugs within the past 30 days; 10. Language communication disorder, unable to complete the cognitive function test; 11. Patients with revision of prosthetic fractures; patients with hip fractures combined with severe trauma to other parts; 12. Those who are allergic to test drugs or have other contraindications to the fascia iliaca.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the spectral features of the frontal electroencephalogram;changes of EEG power before and after anesthesia; | — |
Countries
China
Contacts
Public ContactLiu Xuesheng
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed