Breast cancer
Conditions
Interventions
24 hours after chemotherapy group:Subcutaneous injection of PEG-rhG-CSF 24 hours after chemotherapy
48 hours after chemotherapy group:Subcutaneous injection of PEG-rhG-CSF 48 hours after chemotherapy
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Female patients, pathologically diagnosed female patients with breast cancer; no disease progression or recurrence or distant metastasis has occurred in the standard treatment of breast cancer; 3. The detection values of white blood cells and granulocytes before chemotherapy were normal; 4. The expected survival period is more than 3 months; there are indications for chemotherapy in the treatment plan, and chemotherapy is planned; 5. The main organs of the subjects including heart, liver, lung and kidney function well. Liver function: ALT/AST 60 %; ECOG score less than 2 points; 6. The subjects have not received any radiotherapy, targeted therapy, or endocrine therapy before enrollment.
Exclusion criteria
Exclusion criteria: 1. Those who used granulocyte stimulating factor within 2 weeks before enrollment; 2. Suffering from severe autoimmune disease or immunodeficiency disease; 3. Those suffering from uncontrollable infectious diseases within 2 weeks before enrollment; 4. The investigator believes that there may be any situation that may increase the risk of the subject or interfere with the results of the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of grade 3/4 neutropenia; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse events; | — |
Countries
China
Contacts
Public ContactShi Fujun
Zhujiang Hospital of Southern Medical University
Outcome results
None listed