Metabolic syndrome
Conditions
Interventions
Experimental Group A:Intravenous administration of esketamine loading dose 0.35mg/kg and maintenance dose 0.4mg
Experimental Group B:Intravenous administration of esketamine loading dose 0.2mg/kg and maintenance dose 0.2mg
Control Group:Administer similar amount of normal saline with infusion pump
Experimental Group C:Intravenous administration of esketamine loading dose 0.2mg/kg
Sponsors
The Third People's Hospital of Chengdu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years; 2. ASA classification: I-III; 3. BMI greater than or equal to 27.5 kg/m^2; 4. Laparoscopic bariatric surgery patients; 5. The patient agrees, and the informed consent form must be signed by the patient or his family.
Exclusion criteria
Exclusion criteria: 1. Patients who have not undergone bariatric surgery for the first time; 2. Combined with severe cardiovascular, renal, and liver diseases; 3. Nervous system diseases such as peripheral neuropathy, mental disease; 4. Esketamine contraindications; 5. Untreated or poorly controlled hypertension; 6. Patients with increased intracranial pressure; 7. Glaucoma; 8. Untreated and undertreated patients with hyperthyroidism; 9. Pregnant or breastfeeding women; 10. Drug abuse, including but not limited to opioids, amphetamines, methamphetamine, ketamine, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting NRS pain assessment score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS exercise pain score;Incidence of awakening reactions (many dreams, nightmares, dizziness, restlessness);Extubation Time;The incidence of postoperative nausea and vomiting;Postoperative analgesic drugs that need to be remedied due to the patient’s condition;Total dosage of propofol and remifentanil;The remaining amount of medicine in the analgesic pump;Postoperative hospital stay;Intraoperative circulation; | — |
Countries
China
Contacts
Public ContactFu Qiang
The Third People's Hospital of Chengdu
Outcome results
None listed