osteoporotic vertebral compression fracture
Conditions
Interventions
Intervention group:PKP+zoledronic acid
Controlled group:PKP
Sponsors
Department of Orthopedics, Beijing University of Chinese Medicine Third Affiliated Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Postmenopausal women or adult men with BMD T-score <= 2.5 or less at the lumbar spine measured by dual-energy X-ray absorptiometry (DXA); 2.Isolated compression fracture of single-level vertebral body within 4 weeks; 3.The evidences of vertebral compression fractures were shown by X-ray, and confirmed by MRI. Middle and posterior columns were not affected as shown by CT scanning; 4.Relatively severe back pain exacerbated after activities; 5.Spinal tenderness and/or vertebral body pain with percussion; and 6.Pain that did not improve with control management including bed rest, nonsteroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, and bracing.
Exclusion criteria
Exclusion criteria: 1.Patients with secondary osteoporotic vertebral compression fractures; 2.Patients with symptoms of spinal cord or nerve compression needing fragment excision, decompression, open reduction and internal fixation; 3.Patients complicated with metastasis, multiple myeloma, spinal infection, spinal tuberculosis or hypocalcemia; 4.Patients with severe cardiopulmonary dysfunction, liver failure or renal insufficiency who could not tolerate surgery and anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone mineral density;peptide type I collagen amino end;beta collagen degradation product;osteocalcin in the N-terminal molecular fragment;Visual analogue scale;Oswestry disability index;vertebral height and Cobb angle of injured vertebrae; | — |
Countries
China
Contacts
Public ContactKan Liu
Department of Orthopedics, Beijing University of Chinese Medicine Third Affiliated Hospital
Outcome results
None listed