Thoracic disease
Conditions
Interventions
Experimental group1:The induction dose of S-ketamine was 1mg/kg+ the maintenance dose was 0.15mg/kg/h
Experimental group2:The induction dose of S-ketamine was 1mg/kg+ the maintenance dose was 0.3mg/kg/h
Experimental group3:The induction dose of S-ketamine was 1mg/kg+ the maintenance dose was 0.45mg/kg/h
Control group:Routine anesthesia induction + remifentanil maintenance
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years, no gender restrictions; 2. The single-port thoracoscopic pulmonary surgery is to be performed, and the operation process is simple, and the required time is less than 2 hours; 3. Less airway secretions and no extensive adhesions; 4. American Society of Anesthesiologists ASA I~III grade; 5. Informed consent, voluntarily participate in the trial, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. History of surgery in the pharynx, abnormal tracheal anatomy or lesions involving the bronchi; 2. Patients who are judged to be difficult to manage the respiratory tract (modified Markov score is grade IV); 3. There are infectious lesions in the lungs, and there are more secretions in the airway, or there are symptoms of hemoptysis; 4. Pulmonary function suggests the existence of ventilation and (or) ventilation dysfunction; 5. Anemia or thrombocytopenia, Hb= 2.5 x ULN, TBIL >= 1.5 x ULN; 7. Abnormal renal function, serum creatinine is greater than the upper limit of normal; 8. Those who are allergic to or have contraindications to esketamine, benzodiazepines, opioids, propofol, lidocaine and their drug components; 9. Previous history of mental illness such as depression, schizophrenia, bipolar affective disorder; 10. Obese (body mass index > 30 kg/m2); 11. Subjects deemed unfit for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Waking hours;Time of operation;The proportion of double lumen tubes transferred in the first three groups;The amount of time respiratory depression caused surgery to pause;Incidence of intraoperative cough;Incidence of hypoxemia;Basic vital signs;Postoperative adverse reaction; | — |
Countries
China
Contacts
Public ContactJi Zhonghua
Shanghai East Hospital
Outcome results
None listed