small cell lung cancer
Conditions
Interventions
Experimental group:Synchronous boost accelerated hyperfractionated intensity-modulated radiation therapy combined with concurrent chemotherapy
Sponsors
The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed small cell carcinoma; 2. Aged 18 to 75 years, KPS score >= 80, weight loss within half a year = 1 cm or increased metabolism on PET-CT to consider metastatic lymph nodes); 4. No history of other anti-tumor diseases in the past, no progress in the efficacy evaluation after 2 cycles of EP/EC chemotherapy; Forced expiratory volume in 5.1 seconds (FEV1 >= 1L), neutrophil count >= 1.5 x 10^9/L, hemoglobin >= 100g/L, platelet count >= 100 x 10^9/L, serum creatinine and bilirubin<= 1.5 times the upper limit of normal, AST and ALT <= 2.5 times the upper limit of normal; 6. Fully understand this study, have the ability to complete the treatment, have the conditions for follow-up and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. History of malignant tumors in other parts (previous or concurrent), excluding curable non-melanoma skin cancer and cervical carcinoma in situ; 2. Uncontrolled heart disease or myocardial infarction within the past 6 months; 3. Patients with a history of mental illness; 4. Pregnancy and lactation patients; 5. Uncontrolled diabetes and hypertension; 6. Interstitial pneumonia or active pulmonary fibrosis; 7. Active infection; 8. Others in charge of doctors think that they are not suitable for inclusion in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| local-regional control; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;Progression-free survival;distant metastasis free survival;Toxic and side effects; | — |
Countries
China
Contacts
Public ContactBao Yong
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed